Scientist - Cell Line Engineering
A leading biopharmaceutical company is seeking an experienced Scientist to join their Antibody Cell Line Sciences team. This group sits within the Antibody and Novel Therapeutics function and plays a key role in developing engineered mammalian cell lines that support the manufacture of innovative therapeutic antibodies and complex biologics. This is a hands-on laboratory role focused on host cell line development, cell line engineering, and optimisation of stable mammalian expression systems for antibody production. Key Responsibilities * Establish and develop a toolbox of host cell lines suitable for manufacturing, applying strong laboratory-based scientific expertise * Ensure host systems can express a diverse range of molecule types and meet GMP manufacturing requirements, supported by robust documentation * Engineer and generate stable mammalian cell lines for antibody and novel antibody-format expression * Apply a variety of host engineering and genome editing techniques to develop improved expression systems * Analyse expression and engineering data to draw clear conclusions and inform next steps * Work closely with molecular biology and engineering teams to drive technical progress * Communicate progress effectively across multidisciplinary teams, highlighting risks, issues, and potential opportunities * Maintain accurate documentation and records in line with scientific and regulatory standards Skills & Experience * Minimum BSc in a relevant life sciences discipline * Experience generating stable mammalian cell lines for protein or antibody expression * Strong cell culture expertise, ideally within a biopharmaceutical environment * Experience with genome engineering technologies, such as CRISPR-based cell engineering * Competence in key molecular biology techniques, including ddPCR, cloning, and plasmid construction * Hands-on experience with flow cytometry / FACS and single-cell cloning systems The role is offered on an initial 12 month contract with realistic potential for extension. This is an excellent opportunity to join a collaborative scientific team contributing directly to the development and manufacture of next-generation biologics. VRS9388SE